Ala42S100A8 ameliorates psychological-stress impaired cutaneous wound healing

Cutaneous wound healing is impaired in hemophilia B.

We used a mouse model to test the hypothesis that the time course and histology of wound healing is altered in hemophilia B. Punch biopsies (3 mm) were placed in the skin of normal mice and mice with hemophilia. The size of the wounds was measured daily until the epidermal defect closed. All wounds closed in mice with hemophilia by 12 days, compared with 10 days in normal animals. Skin from the...

Cutaneous wound healing

Mucosal wound healing is impaired by examination stress.

OBJECTIVE Impairment of wound healing is a well-recognized sequelae of conditions that alter immune function, including diabetes, jaundice, and advanced age. There is also growing evidence that psychological stress has adverse consequences for immune function. This study addressed the effects of a commonplace stressor on wound healing. METHOD Two punch biopsy wounds were placed on the hard pa...

THE LANCET Slowing of wound healing by psychological stress

There is evidence that psychological stress adversely affects the immune system. We have investigated the effects of such stress, caused by caring for a relative with Alzheimer's disease, on wound healing. We studied 13 women caring for demented relatives (mean age 62•3 [SE 2•3] years) and 13 controls matched for age (60•4 [2•8] years) and family income. All subjects underwent a 3•5 mm punch bi...

Chemokines in cutaneous wound healing.

Healing of wounds is one of the most complex biological events after birth as a result of the interplay of different tissue structures and a large number of resident and infiltrating cell types. The latter are mainly constituted by leukocyte subsets (neutrophils, macrophages, mast cells, and lymphocytes), which sequentially infiltrate the wound site and serve as immunological effector cells but...